Right ventricular dysfunction persists following brief right ventricular pressure overload

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Right ventricular dysfunction persists following brief right ventricular pressure overload.

OBJECTIVE Acute pulmonary hypertension may cause right ventricular (RV) contractile failure. While it has been assumed that restoration of normal loading conditions after acute pulmonary hypertension is sufficient for complete recovery of RV function, this has not been rigorously examined. The purpose of this study was to test the hypothesis that acute RV pressure overload produces RV contracti...

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Right Ventricular Dysfunction and Failure in Chronic Pressure Overload

Right ventricular (RV) dysfunction is the main cause of death in pulmonary arterial hypertension (PAH). Our understanding of the pathophysiology of RV dysfunction is limited but improving. Methods to better diagnose RV dysfunction earlier and treatments specifically designed to minimize or reverse the remodeling process are likely to improve outcomes. We review the current understanding of RV d...

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Right Ventricular Non-Compaction Cardiomyopathy in Children: Brief Review Literature

      Right ventricular non-compaction cardiomyopathy (RVNC) is a genetic heterogeneous cardiomyopathy. Despite the increasing number of RVNC cases, the classification and natural history of this disorder are not completely clear. Also, because the pathogenic non-compaction cannot be easily differentiated from normal trabeculations, it is usually hard to accurately measure the prevalence of RV ...

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Right ventricular pressure and dilation during pressure overload determine dysfunction after pressure overload.

Volume expansion and inotropic stimulation are used clinically to augment cardiac output during acute right ventricular (RV) pressure overload. We previously showed that a brief period of RV pressure overload causes RV free wall dysfunction that persists after normal loading conditions have been restored. However, the impact of volume expansion and inotropic stimulation on the severity of RV dy...

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Right atrial and ventricular adaptation to chronic right ventricular pressure overload.

BACKGROUND Increased mortality in patients with chronic pulmonary hypertension has been associated with elevated right atrial (RA) pressure. However, little is known about the effects of chronic right ventricular (RV) pressure overload on RA and RV dynamics or the adaptive response of the right atrium to maintain RV filling. METHODS AND RESULTS In 7 dogs, RA and RV pressure and volume (conduc...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 1997

ISSN: 0008-6363

DOI: 10.1016/s0008-6363(97)00038-2